Ko te fibrosis puku i puta mai i te hihi-ā-rangi he raruraru noa iho mō te hunga i ora tonu i muri i te radiotherapy puku me te hope. I tēnei wā, kāore he tikanga haumanu e wātea ana hei rongoā i te fibrosis puku i puta mai i te hihi-ā-rangi. Kua whakaatuhia e ngā rangahau he kaha te nicotinamide mononucleotide (NMN) ki te whakahaere i ngā tipu puku. Ko te tipu puku he moroiti noa i roto i ngā whekau tangata, ka taea te hanga i ngā momo matūkai e tika ana mō te tipu me te whanaketanga o te tangata. Kia kore e taurite ngā tipu puku, ka puta he maha ngā mate.
Nō nā tata nei, i whakaputahia e te China Academy of Medical Sciences me te Peking Union Medical College ngā hua rangahau i roto i te puka International Journal of Radiation Biology, i whakaatu ai ka taea e te NMN te whakaiti i te fibrosis puku i puta mai i te radiation mā te whakahaere i ngā tipu puku.
I te tīmatanga, i wehea e te tīma rangahau ngā kiore ki te rōpū whakahaere, te rōpū NMN, te rōpū IR me te rōpū NMNIR, ā, i hoatu he irahiko puku 15 Gy ki te rōpū IR me te rōpū NMNIR. I taua wā, i hoatu he tāpiringa NMN ki te rōpū NMN me te rōpū NMNIR i te horopeta o ia rā o te 300mg/kg. I muri i te tangohanga mō tētahi wā, mā te kite i ngā paru kiore, ngā microflora puku me ngā tohu kiko koroni, i whakaatuhia e ngā hua whakatairite:
1. Ka taea e te NMN te whakatika i te hanganga me te mahi a ngā tipu puku e whakararuraruhia ana e te irahiko.
Mā te whakataurite i te kitenga o ngā tipu puku i waenga i te rōpū IR me te rōpū NMNIR, i kitea ko ngā kiore rōpū IR i whakanui ake i te nui o ngā tipu puku kino, pērā i te Lactobacillus du, Bacillus faecalis, me ētahi atu. He mea whakamiharo, i whakarerekē ngā kiore rōpū NMNIR i te kanorau o ngā tipu puku, ā, i whakanui ake i te nui o ngā tipu puku whai hua, pērā i te huakita AKK, mā te tāpiri i te NMN. E whakaatu ana ngā whakamātautau ka taea e te NMN te whakatika i te hanganga me te mahi o ngā tipu puku kua kore e taurite nā te irahiko.
2. Ka whakamama te NMN i te fibrosis puku i puta mai i te irahiko
I tino piki ake te taumata o te aSMA (Fibrosis Marker) i roto i ngā kiore i pāngia e te irahiko. Whai muri i te tāpiringa NMN, ehara i te mea ko te taumata o te tohu aSMA anake i heke nui, engari ko te tauwehe mumura TGF-b i whakatairanga i te fibrosis puku i heke nui, e tohu ana ka taea e te tāpiringa NMN te whakaiti i te fibrosis puku i puta mai i te irahiko.
(Pikitia 1. Ka whakaitihia e te maimoatanga NMN te fibrosis puku i puta mai i te irahiko)
I raro i te papamuri o te horapa o ngā hua hiko, ka piki haere te pānga o te irahiko ki te mahi me te oranga o te tangata, inā koa ki ngā tipu puku mō te wā roa. He kaha te pānga tiaki a te NMN ki te hauora o te puku. Ehara i te mea ka kitea tēnei pānga e te matū kotahi, e te ara rānei, engari mā te whakahaere i te hanganga tohatoha o ngā tipu hei whakatairanga i te pumau o te mahi puku mai i ngā koki me ngā ahunga rerekē, e whakarato ana hoki i tētahi tohutoro nui mō ngā painga maha o te NMN.
Ngā Tohutoro:
Xiaotong Zhao, Kaihua Ji, Manman Zhang, Hao Huang, Feng Wang, Yang Liu & Qiang Liu (2022): NMN e whakaiti ana i te fibrosis intestinal iraruraru ma te whakarereke i te microbiota gut, International Journal of Radiation Biology, DOI: 10.1080/09553002.2023
Wā tuku: Hakihea-08-2022