Ko te whakahohenga o ngā macrophage he tikanga mate e arahi ana ki te mumura mau tonu i roto i te tinana, engari ko te whakahohenga tonu o ngā macrophage ka arahi pea ki te mumura mau tonu me ngā mate pēnei i te ātete ki te insulin me ngā mate kino pēnei i te atherosclerosis. Ko te PGE 2, e whakahaere ana i te urupare mumura, ka hangaia mai i te waikawa arachidonic e ngā cyclooxygenases (COX-1 me te COX-2). Ko te COX-1 me te COX-2 ngā whāinga matua o te anti-inflammatory, ā, ka taea te aukati e ngā rongoā anti-inflammatory kore-steroidal (NSAID).
Ka taea e te whakamahinga o ngā NSAID te whakaputa i ngā pānga kino maha, pērā i te toto i roto i te puku. Nō reira, he mea tino nui kia kitea he matū taiao haumaru ake hei rongoā i te mumura.
Nō nā tata nei, i rongoatia e tētahi rōpū rangahau nō Te Whare Wānanga o Tsinghua ngā macrophage kiore ki te NMN, ā, i whakamāramahia mā roto i ngā whakamātautau ka taea e te NMN te whakaiti i te kohikohinga o ngā pūmua e pā ana ki te mumura me ngā hua taha pākia, me te aukati i te urupare mumura o ngā macrophage. Ngā Rohe i roto i ngā Pūtaiao Koiora Molecular.
Ka whakarerekē te mumura i ngā taumata o ngā hua taha pākia i roto i ngā macrophages
Tuatahi, i whakahohe te tīma rangahau i ngā macrophage hei whakaputa mumura mā te lipopolysaccharide (LPS), kātahi ka tātarihia te ihirangi o ngā hua taha huri noa i ngā macrophage i te wā o te mumura. I piki ake ngā taumata o te 99 metabolites, ā, i heke iho te 105 metabolites i roto i ngā ngota 458 i kitea i mua atu me muri i te whakaoho mumura, ā, i heke iho hoki ngā taumata NAD+ e haere tahi ana me te mumura.
(WHAKAAHUA 1)
Ka whakanui te NMN i ngā taumata NAD me te whakaiti i te mumura o te macrophage
I muri mai ka rongoāhia e te tīma rangahau ngā macrophage ki te LPS, e puta ai he āhua mumura, IL-6 me te IL-1β, arā, ngā cytokine pro-inflammatory e mahi ana hei tohu mō te mumura. I muri i te rongoā NMN mō te mumura macrophage i puta mai i te LPS, i kitea kua piki ake te taumata NAD i roto i te pūtau, ā, kua heke te whakaaturanga mRNA o te IL-6 me te IL-1β. I whakaatuhia e ngā whakamātautau i whakanui ake te NMN i te taumata o te NAD, ā, i whakaiti i te mumura macrophage i puta mai i te LPS.
(Pikitia 2)
(Pikitia 3)
Ka whakaitihia e te NMN ngā taumata pūmua e pā ana ki te mumura
I roto i te maimoatanga NMN, i kitea kua heke ngā pūmua e pā ana ki te mumura pērā i te RELL1, PTGS2, FGA, FGB me te igkv12-44 i roto i ngā pūtau, e tohu ana i te whakaiti a te NMN i te whakaaturanga o ngā pūmua e pā ana ki te mumura.
(Pikitia 4)
Ka whakaitihia e te NMN te whakaaturanga o ngā pūmua ūnga NSAIDS
I kitea i te whakamātautau whakamutunga i whakaitihia e te NMN te taumata o te PGE2 i roto i ngā pūtau RAW264.7 i whakahohehia e te LPS mā te whakaiti i te taumata whakapuakanga o te COX-2, ā, nā reira ka whakaitihia te whakapuakanga o te COX2 me te aukati i te mumura i puta mai i te LPS.
(Pikitia 6)
Ko te whakatau, mā te tāpiritanga o te NMN ka taea te rongoā i te mumura mau tonu i roto i ngā kiore, ā, me manatoko tonu te rongoā i te mumura i roto i te tangata mā roto i ngā whakamātautau haumanu e tika ana. Tērā pea ka noho te NMN hei whakakapi mō ngā NSAIDS a te wā tata nei.
ngā tohutoro:
1.Liu J, Zong Z, Zhang W, Chen Y, Wang X, Shen J, Yang C, Liu X, Deng H. Ko te Nicotinamide Mononucleotide te whakaheke i te LPS-Induced Inflammation and Oxidative Stress mā te Whakaheke COX-2 Expression in Macrophages. Tuhinga o mua Mol Biosci. 2021 Hurae 6.
Wā tuku: Whiringa-ā-rangi 26-2022