Ko te Clenbuterol, he β2-adrenergic agonist (β2-adrenergic agonist), he rite ki te ephedrine (Ephedrine), he maha ngā wā e whakamahia ana i roto i te rongoā hei rongoā i te mate pūkahukahu aukati mau tonu (COPD), ka whakamahia hoki hei bronchodilator hei whakaora i ngā whakaekenga ohorere o te huango. I te tīmatanga o te tekau tau atu i 1980, i kitea ohoreretia e te kamupene Amerika Cyanamid he pānga kitea ki te whakatairanga i te tipu, te whakapai ake i te tere o te mīti kikokore me te whakaiti i te ngako, nō reira i whakamahia ai hei clenbuterol i roto i te mahi ahuwhenua kararehe. Heoi, nā ōna pānga taha, i aukatia e te Hapori Pākehā te whakamahinga o te clenbuterol hei tāpiringa whāngai mai i te 1 o Hānuere, 1988. I aukatia e te FDA i te tau 1991. I te tau 1997, i tino aukatia e te Manatū Ahuwhenua o te Repupiripia o Haina te whakamahinga o ngā homoni beta-adrenergic i roto i te mahi ahuwhenua me te mahi ahuwhenua kararehe, ā, ko te Clenbuterol hydrochloride te tuatahi.
Heoi, kua whakaaturia tata nei te kaha o te Clenbuterol racemic ki te whakaiti i te mōrearea o te mate a Parkinson. Hei whakaū ko ēhea (ko ēhea rānei) ngā isomers e whakaputa ana i tēnei pānga, me ako motuhake te enantiomer Clenbuterol parakore.
I roto i tētahi tuhinga hou, i whakahaerehia e te rōpū rangahau a Elisabeth Egholm Jacobsen o te Tari Matū, Te Whare Wānanga o te Pūtaiao me te Hangarau o Nōwei, me te mahi tahi me Tākuta Zhu Wei o Shangke Bio, te hanganga o te ketoreductase KRED me te cofactor nicotinamide adenine dinucleoside phosphate (NADPH). (R)-1-(4-Amino-3,5-dichlorophenyl)-2-bromoethan-1-ol, ee > 93%; ā, i hangaia te (S)-N-(2 e te pūnaha kotahi, 6-Dichloro-4-(1-hydroxyethyl)phenyl)acetamide, ee >98%. Ko ngā takawaenga e rua o runga ake nei he matū mua pea o ngā isomers clenbuterol. Ko te ketoreductase ES-KRED-228 i whakamahia i roto i tēnei rangahau i ahu mai i Shangke Biopharmaceutical (Shanghai) Co., Ltd. Ko te hua rangahau "Chemoenzymatic Synthesis of Synthons as Precursors for Enantiopure Clenbuterol and Other -2-Agonists" i whakaputaina ki roto i te "Catalysts" i te 4 o Noema, 2018.
Wā tuku: 26 o Ākuhata-2022