He mate kiri te ngoikore o te kiri, ko te nuinga o te wā ka kitea mā te whakaiti i te melanin. Ko ngā tohu noa ko te vitiligo, te albinism me te ngoikore o te kiri i muri i te mumura o te kiri. I tēnei wā, ko te rongoā waha te rongoā matua mō te ngoikore o te kiri, engari ka pāngia te kiri e te rongoā waha, ka mamae te puku me ētahi atu pānga kino. Nō reira, me whakawhanake he matū taiao kāore he pānga kino hei rongoā i te ngoikore o te kiri.
Nō nā tata nei, i whakaputa a Scientific Reports i tētahi tuhinga ko "He tūhuratanga pūnaha e whakaatu ana i te kaha o te spermidine mō te maimoatanga o te whakahekenga kiri mā te whakau i ngā pūmua e pā ana ki te melanogenesis". E whakaatu ana ngā hua ka taea te rongoā i te spermidine mā te whakau i ngā pūmua e pā ana ki te melanogenesis.
Ka whakanui ake te maimoatanga spermidine i te hanga melanin
Hei ako i te pānga o te spermidine ki te hanga melanin, i rongoāhia e te tīma rangahau te melanin i roto i ngā pūtau MNT-1 ki ngā kukū rerekē o te spermidine. Mā te tātaritanga tauanga, i kitea ko te rongoā spermidine i whakapiki ake i te hanga melanin.
Ka taea e te Spermidine te whakahaere i te pūnaha pakaru pūmua e pā ana ki te melanogenesis
Hei whakaatu i te kaha o te spermidine ki te whakahaere i ngā ira e uru ana ki te whakahekenga pūmua, i kitea e te tīma rangahau he 181 ngā ira kua whakahekehia te whakahaere me te 82 ngā ira kua piki ake te whakahaere mā te kimi pūnaha i ngā pūtau kua rongoatia ki te spermidine, me te kore e whakauru i ngā ira e pā ana ki te melanogenesis. Hei whakaatu anō, i tātarihia e te tīma rangahau te pānga o te spermidine ki te taumata whakapuakanga o te whānau ira tyrosinase TYR, TRP-1 me te TRP-2, arā, he ira e whakahaere tata ana i te hanga melanin. I whakaū te taumata whakapuakanga mRNA kāore te spermidine i whakarerekē i te whakapuakanga o ngā ira e pā ana ki te melanogenesis. Heoi, ka whakarerekētia te mahi a ētahi ira e te spermidine, ā, e pā ana ki te whakahekenga pūmua. He maha ngā ira kua whakarerekētia e pā ana ki te ubiquity, he pūnaha whakahekenga pūmua e pā ana ki te melanogenesis.
Tuatahi. Ka whakahaere te spermidine i te pumau o ngā pūmua me te whakatairanga i te hanga melanin.
Ko te hanga o te melanin ka whakahaeretia e te taurite o te hanga me te pakaru o ngā pūmua e pā ana ki te melanin. Ka rongoatia e te Spermidine ngā ira TYR, TRP-1 me te TRP-2. Mā te mahi a ngā ira kawe SLC3A2, SLC7A1, SLC18B1 me te SLC22A18, ka taea e ia te whakanui ake i te taumata o ngā polyamine i roto i ngā pūtau, ā, ka whakanui ake i te pumau o ngā pūmua e pā ana ki te hanga melanin hei whakatairanga i te hanga melanin i roto i te tinana ora.
Hei whakamutunga, e whakaatu ana tēnei rangahau he mahi pea tā te matū tūturu spermidine ki te rongoā i te ngoikore o te kiri, ā, he uara anō tōna mō te whakamahinga i roto i te ao o ngā mea whakapaipai me ngā hua hauora ā muri ake nei.
Tohutoro:
[1]. Brito, S., Heo, H., Cha, B. et al. E whakaatu ana tētahi rangahau pūnaha i te kaha o te spermidine mō te maimoatanga o te whakahekenga kiri mā te whakau i ngā pūmua e pā ana ki te melanogenesis.Sci Rep 12, 14478 (2022). https://doi.org/10.1038/s41598-022-18629-3.
Wā tuku: Hepetema-28-2022