Te whakahekenga imine (IRED)
Whakaahuatanga Poto:
Mō te Imine reductase
ES-IRED: He momo whākōkī e whakakorikori ana i te whakaiti i te here C=N ki te here CN. Nō te whākōkī redox, me te coenzyme NADPH mō te kawe hauwai. E ai ki te hiahia chiral o ngā hua, ka taea te wehewehe ki a R-IRED me S-IRED. I whakawhanakehia e ngā Syncozymes te 15 imine reductases (numbIRED ES-IRED-101-ES-IRED-115), ka taea te whakamahi whānui i roto i te whakaiti regioselective me te stereoselective o ngā imines hei whakarite i ngā amine chiral.
Momo tauhohenga whakakorikori:
Waea Pūkoro/Wechat/WhatsApp: +86-13681683526
Ī-mēra:lchen@syncozymes.com
| Ngā whākōkī | Waehere Hua | Whakatakotoranga |
| Paura whākōkī | ES-IRED-101~ ES-IRED-114 | he huinga o te 14 Imine Reductase, 50 mg ia |
| Kete Tirotiro Whākōkī 96-Well | ES-IRED-1400 | he huinga o te 14 Imine Reductase, 1 mg ia |
★ Teitei o te motuhaketanga o te papa.
★ He kaha te whiriwhiringa chiral.
★ Te tahuritanga teitei.
★ He iti ake ngā hua taha.
★ Ngā āhuatanga tauhohenga ngawari.
★ He pai mō te taiao.
➢ I te nuinga o te wā, me whakauru e te pūnaha tauhohenga te matūriki, te otinga ārai, te whākōkī, te koehaukino, me te pūnaha whakaora koehaukino.
➢ Me ako takitahi ngā momo ES-IRED katoa e pā ana ki ngā āhuatanga tauhohenga tino pai.
➢ Ka ārai pea te matūriki, te hua rānei e mau ana i te kukū tiketike i te mahi a te ES-IRED. Heoi, ka taea te whakaiti i te aukati mā te tāpiri puranga o te matūriki.
Tauira 1 (Te hanga koiora o te 2-methyl pyrrolidine chiral)(1):
Tauira 2 (Te hanga koiora o te amine tuarua)(2):
Tauira 3 (Te Whakaiti i ngā Imine Hurihuri)(3):
Puritia mō ngā tau e rua i raro i te -20℃.
Kaua rawa e pā ki ngā āhuatanga tino kino pēnei i: te pāmahana teitei, te pH teitei/iti me te whakarewa waro kukū teitei.
1. Scheller PN, Fademrecht S, Hofelzer S, et al. ChemBioChem, 2014, 15, 2201-2204.
2. Wetzl D, Gand M, Ross A, me ētahi atu. ChemCatChem, 2016, 8, 2023-2026.
3. Li H, Luan ZJ, Zheng GW, et al. Adv. Synth. Catal. 2015, 357, 1692-1696.
