β-Nicotinamide adenine dinucleotide (waikawa kore utu) (NAD)
Ko te NAD he coenzyme tino noa o te dehydrogenase i roto i ngā mea ora. Ka whai wāhi atu ki ngā tauhohenga redox i roto i ngā mea ora, ā, ka kawe me te whakawhiti irahiko mō ngā matū i roto i te tauhohenga. He mahi nui tā te dehydrogenase i roto i te pākia o te tangata. Ko ētahi o ngā nekehanga pākia taketake o te tinana tangata, pērā i te wetewete pūmua, te wetewete warowaihā, me te wetewete ngako, kāore e taea te whakahaere noa me te kore he dehydrogenase, ā, ka ngaro ngā tohu ora o te tangata. Nā te mea ka taea e te whakakotahitanga o te NAD me te dehydrogenase te whakatairanga i te pākia o te tinana, nō reira he wāhanga nui o te tinana tangata te NAD. E ai ki te whakamahinga o te hua, ka taea te wehewehe ki ēnei taumata: te taumata biotransformation, te taumata diagnostic reagent, te taumata kai hauora, te API me ngā rauemi mata whakarite.
| Ingoa Matū | Nicotinamide adenine dinucleotide (waikawa kore utu) |
| Ngā kupu taurite | β-Nicotinamide adenine dinucleotide |
| Tau CAS | 53-84-9 |
| Taumaha ngota | 663.43 |
| Tātai Ngota | C21H27N7O14P2 |
| EINECS ingoa: | 200-184-4 |
| Te pūwāhi rewa | 140-142 °C (whakakore) |
| pāmahana rokiroki | -20°C |
| te wairewatanga | H2O: 50 mg/mL |
| puka | Paura |
| tae | Mā |
| Merck | 14,6344 |
| BRN | 3584133 |
| Te pumau: | Pūmau. Ātete ki te wai. Kāore e hototahi ki ngā matū whakahāora kaha. |
| InChIKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Tūemi Whakamātautau | Ngā Whakatakotoranga |
| Āhua | Paura tioata mā ki te mā-parauri |
| Tātaritanga hihi UV εi te 260 nm me te pH 7.5 | (18±1.0)×10³ L/mol/cm |
| Te wairewatanga | 25mg/mL 25mg/mL i roto i te wai |
| Ihirangi (mā te tātari whākōkī me te ADH i te pH 10, mā te whakamahi i te ine ine, abs.340nm, i runga i te pūtake waikore) | ≥98.0% |
| Whakamātautau (mā te HPLC, i runga i te pūtake waikore) | 98.0~102.0% |
| Te Parakore (mā te HPLC, %rohe) | ≥99.0% |
| Te nui o te wai (nā KF) | ≤3% |
Mōkihi:Pounamu, putea konumohe, 25kg/Pahu Kāri, kia rite rānei ki te hiahia o te kiritaki.
Āhuatanga Rokiroki:Puritia kia mau te taupoki i roto i te pōuri, kia roa te rokiroki, puritia ki te 2~8℃.
Te taumata whakawhiti koiora: Ka taea te whakamahi mō te hanga matū koiora o ngā takawaenga rongoā me ngā API, ko te nuinga me ngā whākōkī matū koiora, pērā i te ketoreductase (KRED), te nitroreductase (NTR), te P450 monooxygenase (CYP), te formate dehydrogenase (FDH)), te glucose dehydrogenase (GDH), me ētahi atu, ka taea te mahi tahi ki te huri i ngā takawaenga waikawa amino me ētahi atu rongoā e pā ana. I tēnei wā, kua tīmata te maha o ngā wheketere rongoā ā-rohe ki te whakamahi i te whakakapinga whākōkī koiora, ā, kei te tere tipu te hiahia o te mākete mō te NAD+.
Te tohu matū tātaritanga: I honoa ki te maha o ngā whākōkī tātaritanga, hei rauemi mata mō ngā kete tātaritanga.
Kai hauora: Ko te NAD he coenzyme o te dehydrogenase. He mahi nui tāna i roto i te glycolysis, te gluconeogenesis, te huringa waikawa tricarboxylic, me te mekameka manawa, he mahi nui tāna i roto i te whakaputa pūngao, ā, he āwhina i te whakaputanga o te L-dopa, ka huri hei dopamine Neurotransmitters. Ina koa i ngā tau tata nei, kua kitea ko ia te "mīhini" me te "wahie" i roto i te tukanga whakatika i ngā kino o ngā pūtau. E ai ki ngā rangahau, ko te tāpiritanga o ngā coenzyme (tae atu ki te NMN, NR, NAD, NADH) i roto i te vitro ka taea te whakarei ake i te kaha antioxidant o ngā pūtau kiko, te aukati i te tohu apoptosis, te whakahoki mai i te mahi noa o ngā pūtau, te aukati i te putanga mai o te mate, te aukati rānei i te haere whakamua o te mate.
Hei tāpiritanga, ka taea e ngā coenzyme te whakarei ake i te kaha o te urupare ārai mate mā te whakahohe me te whakatairanga i te pakeketanga o ngā pūtau ārai mate ā-roto, te whakaputa i ngā āhuatanga ārai-mumura me te pehi i ngā pūtau-T whakahaere. Ko te āhua whakahāngaitanga nicotinamide dinucleotide (NAD+) he coenzyme e kitea ana i roto i ngā pūtau ora katoa. He mahi nui tāna i roto i ngā rau o ngā tukanga pākia i roto i ngā pūtau, e whai wāhi ana ki ngā mano o ngā tauhohenga ā-tinana, ā, ko ia te mema tino nui o te mekameka kawe irahiko. Ko te kaituku hauwai; i te wa ano, ko te coenzyme I te mahi hei turanga kotahi mō ngā whākōkī e pā ana ki roto i te tinana, e āwhina ana ki te pupuri i te mahi a ngā whākōkī.
Ko te Nicotinamide mononucleotide (NMN) te matū matua o te āhua whakapūngao nicotinamide adenine dinucleotide (NAD+), e whai wāhi ana ki te hanga o te NAD i roto i te tinana ora. I te tau 2013, i kitea e te Ahorangi David Sinclair o te Kura Hauora o Harvard, i te pakeketanga, ka heke tonu te taumata cofactor coenzyme I (NAD+) o te pūmua roa i roto i te tinana, ka heke te mahi mitochondrial o te "dynamo" o te pūtau, ka whakaoho i te koroheketanga, me ngā āhuatanga rerekē o te tinana. Nō reira ka puta te hapa o tēnei momo mahi. E ai ki āna rangahau, ka heke te nui o te NAD+ i roto i te tinana tangata i te pakeketanga, ka tere ake te koroheketanga mai i te 30 tau te pakeke, me ngā kita, te whakangāwari o te uaua, te kohikohi ngako, me ngā mate pēnei i te mate ngakau, te toto toto tiketike, te whiu, te mate huka me te mate a Alzheimer. Ko te kī ki te roanga o te ora ko te whakanui ake i te taumata o te coenzyme I (NAD+) i roto i te tinana, te whakanui ake i te tere o te pākia o te pūtau, me te whakaoho i te kaha o te taitamarikitanga.
Ngā rauemi mata o te API me te whakarite: Ka whakamahia te NAD+ i roto i ngā werohanga hei rongoā/whakahaere i te waranga tarukino, tae atu ki te rongoā NAD IV i whakatinanahia ki te United States, Europe, Russia, South Africa, Mexico, America South, Southeast Asia me ētahi atu whenua. Ko ngā hua rongoā i whakaritea e rātou anō, he rite ki ngā rongoā o Amerika, ka taea te hoko rauemi mata hei tohatoha mā rātou anō, pērā i ngā whakaritenga hōhipera Hainamana, ka whakahaere i te kounga o ngā rauemi mata mā rātou anō, ā, ka whakarite i ngā whakaritenga hei rongoā.
