I a tātou e pakeke haere ana, ka pakarukaru ō tātou wheua, ka whati hoki, ā, he iti noa iho te kaha o ngā maimoatanga o nāianei ki te whakanui ake i te kiato o te wheua. Ko te nuinga o tēnei raruraru ka puta ake nā te mea kāore i te mōhiotia te pūtake o te osteoporosis (te hekenga o te papatipu me te kiato o te wheua).
Nō nā tata nei, i whakaputa ngā kairangahau o Ahitereiria i ngā hua rangahau pūtaiao ki te Journal of Gerontology: Series A: Ka taea e te NMN te whakaiti i te koroheketanga o ngā pūtau wheua tangata me te whakatairanga i te whakaora wheua i roto i ngā kiore osteoporosis. "E whakaatu ana ngā kitenga i te NMN hei rongoā whai hua me te whai hua hei ārai i te osteoporosis me te whakarei ake i te whakaora wheua i roto i ngā kaumātua e pangia ana e te osteoporosis," te kī a ngā kaituhi.
一,NMNka whakatairanga i te whakaora o ngā osteoblast me te whakanui ake i te rahi o te wheua
Pērā i ētahi atu okana o te tinana tangata, he pūtau ora te hanganga o ngā wheua. Nō reira, ka whakakapia tonutia ngā wheua tawhito me ngā wheua pakaru ki ngā wheua hou. Heoi, i a tātou e pakeke haere ana, ka iti ake ngā osteoblast e wātea ana, nā te mea ka noho ngā osteoblast noa hei pūtau tawhito. Kāore e taea e ngā pūtau tawhito, e ārahi ana i te tukanga koroheketanga, te hanga wheua hou, ka arahi ki te osteoporosis.
I rangahauhia e ngā kairangahau o Ahitereiria ngā pānga o te NMN ki te osteoporosis mā te ako i ngā osteoblast tangata. Hei whakaoho i te koroheketanga, i whakaatuhia e ngā kairangahau ngā osteoblast ki tētahi mea e whakaoho ana i te mumura e kiia nei ko te TNF-⍺. Ahakoa ka tere ake te koroheketanga o te TNF-⍺, i whakaitihia e te maimoatanga ki te NMN te koroheketanga tata ki te 3 ngā wā, ā, i whakaatuhia e ngā hua ka whakaitihia e te NMN ngā osteoblast koroheketanga.
Ka hangaia e ngā osteoblast hauora he kiko wheua hou mā te huri hei pūtau wheua pakeke. I kitea e ngā kairangahau mā te whakaoho i te koroheketanga me te TNF-⍺ ka whakaitihia te nui o ngā pūtau wheua pakeke. Heoi, i whakanuia e te NMN te nui o ngā pūtau wheua pakeke, ā, e kī ana ngā hua ka taea e te NMN te whakatairanga i te hanganga wheua.
I muri i te whakapumautanga o ngā kitengaNMNka taea te whakaiti i ngā osteoblast kua koroheke, me te whakatairanga i tō rātou rerekētanga hei pūtau wheua pakeke, i whakamātauhia e ngā kairangahau mēnā ka puta tēnei i roto i ngā mea ora. Hei mahi i tēnei, i tangohia e rātou ngā ovaries o ngā kiore uha, ā, i whatiia ō rātou femur, ka hua ake te ngaronga o te papatipu wheua e kitea ana i te osteoporosis.
Hei whakamātautau i te pānga o te NMN ki te osteoporosis, i werohia e ngā kairangahau ngā kiore osteoporosis ki te 400 mg/kg/rā o te NMN mō ngā marama e rua. I kitea kua piki ake te papatipu wheua o ngā kiore osteoporosis, e tohu ana i te whakakorenga ā-wāhanga o ngā tohu o te osteoporosis e te NMN. I te honoa ki ngā raraunga osteoblast tangata, ko te tikanga ka taea e te NMN te rongoā i te osteoporosis mā te whakanui ake i te hanganga wheua.
二、 Nga hua whakaniko iwi o te NMN
E whakaatu ana ngā hua rangahauNMNka taea te whakatairanga i te hanganga wheua. Te āhua nei he maha ngā huarahi e mahi ai tēnei, tae atu ki te whakahou i ngā pūtau take wheua, he mea nui mō te hanganga wheua me te NAD+, he mea nui mō te hanganga wheua. Ka rerekē ngā pūtau take wheua hei osteoblast, ā, kua whakaatuhia e ngā kairangahau ka taea hoki e te NMN te whakahou i ngā osteoblast.
E whakaatu ana ēnei kitenga ka taea e te NMN te whakanui ake i te hanganga wheua mā te whakatairanga i te hauora o ngā pūtau wheua maha i roto i te ara hanganga wheua. Ahakoa kāore he hua rangahau e whakaatu ana ka taea e te NMN te whakatairanga i te hanganga wheua i roto i te hunga e pāngia ana e te osteoporosis, tera pea ka taea e te NMN te aukati i te whanaketanga o te wheua e puta ana i te kaumātuatanga.
Wā tuku: Hanuere-18-2024