Te Pūnaha Whakapūngao: Te pānga rongoā o te tāpiringa NMN ki te mate ovary polycystic

I ngā tau tata nei, nā te pikinga ake o ngā momo noho kino me te pikinga ake o te pēhanga pāpori o ngā wāhine, kua tino kitea te auau o te mate o te polycystic ovary syndrome (PCOS). Kua whakaatuhia e ngā rangahau o tāwāhi ko te auau o te mate o te polycystic ovary syndrome (PCOS) i roto i ngā wāhine e whānau ana he 6% -15%, engari i Haina, ko te ōwehenga he 6% -10%.

Ko te mate ovarian polycystic he mate e pā pinepine ana ki ngā wāhine whānau tamariki nā ngā mate endocrine. Ko te nuinga o te wā ka kitea i roto i te koretake o te pākia o te huka me te ngako me te ngoikore o te whakaputa uri. Ko ngā paearu tātaritanga haumanu ko te mate taumata homoni (te androgen teitei), ngā mate huango waimeha me ngā huringa polycystic ovarian, ā, ko te nuinga o ngā wāhine whai PC COS he āhuatanga pākia kino, pērā i te ātete insulin, te momona, me te steatosis ate.

I tēnei wā, he iti noa ngā rongoā hei rongoā i te PCOS. Ko te tikanga noa ko te whakapai ake i te PCOS mā te arotahi me te aukati i te nui o te androgen me ngā rongoā anti-androgen. Heoi, kei reira anō ngā taunakitanga he kaha te paitini o ngā rongoā anti-androgen ki te ate, nō reira he iti noa iho te whakamahinga. Nō reira, he mea tino nui te rapu i tētahi matū taiao kāore he pānga taha hei whakakapi i ngā rongoā o nāianei.

I kitea i roto i tētahi rangahau hou nā Te Whare Wānanga o New South Wales i Ahitereiria he hononga tō te mate ovary polycystic ki te korenga o te NAD+, ā, i whakaputaina ngā hua o te rangahau ki te puka pūtaiao "Molecular Metabolism".

I te tuatahi, i whakatōngia e te tīma rangahau te dihydrotestosterone (DHT) ki raro i te kiri o ngā kiore uha i mua atu, ā, i muri i te pakeketanga hei whakatū i tētahi tauira kiore PC COS, ā, i muri i ngā wiki e 8 o te maimoatanga NMN, te kimi i te insulin nohopuku me te ātete HOMA insulin, te whakamātautau manawanui huka, te ngako. I muri i ngā whakamātautau pēnei i te histomorphometry, e whakaatu ana ngā hua tatauranga:

1. Ka whakahokia mai e N MN te taumata N AD+ i roto i te uaua o ngā kiore P COS
i kitea kua tino heke te taumata NAD+ i roto i te uaua o ngā kiore PCOS, ā, i whakahokia mai te taumata NAD i roto i te uaua o ngā kiore PCOS mā te whāngai NMN.

2. Ka whakapai ake te NMN i te ātete ki te insulin me te momona i roto i ngā kiore PCOS
Neke atu i te rua te pikinga o ngā taumata insulin i puta mai i te DHT i roto i ngā kiore PCOS nohopuku, he tohu pea tēnei i te ātete ki te insulin. Mā te whāngai i te NMN, i kitea kua whakahokia te taumata insulin nohopuku ki te taumata tata ki te taumata o ngā kiore noa. Hei tāpiri, i piki ake te taumaha tinana o ngā kiore PCOS mā te 20%, ā, i tino piki ake te papatipu ngako.

3. Ka whakahokia mai e te NMN te whakatakotoranga ngako ate rerekē i roto i ngā kiore PCOS
Ko tētahi o ngā āhuatanga o te mate ovary polycystic ko te whakatakotoranga ngako ki roto i te ate me te whakaoho i te ate momona. Whai muri i te tango i te NMN, tata kore te whakatakotoranga ngako ate rerekē i roto i ngā kiore PCOS, ā, kua hoki ngā triglycerides i roto i te ate ki te taumata noa o ngā kiore.

Hei whakatau, i tino heke te taumata o te NAD+ i roto i te uaua o te PCOS, ā, i whakamamahia te āhua o te PCOS mā te tāpiri i te NMN, te matūtake o te NAD+, he rautaki rongoā pea tēnei mō te maimoatanga o te PCOS.

ngā tohutoro:
[1]. Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA. Te whakahekenga o te uaua NAD+ i roto i te tauira kiore PCOS hyperandrogenism: He tūranga pea i roto i te korenga o te whakahaerenga o te pūnaha io. Mol Metab. 2022 Sep 9;65:101583. doi: 10.1016/j.molmet.2022.101583. Epub i mua i te tānga. PMID: 36096453.