Whakaahua Matua o te Esterase&Lipase (PLE&CALB)

Esterase me te Lipase (PLE me te CALB)

Whakaahuatanga Poto:

Mō Esterase me Lipase

ES-PLE: He momo hydrolases e whakakorikori ana i te hanganga me te pakaru o ngā here ester. Ka taea e rātou te whai wāhi ki ngā momo tauhohenga matū koiora maha, pērā i te esterification, te transesterification me te hydrolysis. He whānuitia te whakamahinga i roto i ngā mara maha pērā i te tukatuka kai, te ahumahi matū, te rongoā koiora, te rongoā chiral me te maimoatanga taiao.

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Ī-mēra:lchen@syncozymes.com

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Taipitopito Hua

Ngā Tohu Hua

Mō te Esterase me te Lipase:

E 26 ngā momo hua whākōkī PLE (Tau ko ES-PLE-101～ES-PLE-126) i whakawhanakehia e SyncoZymes. Ka taea te whakamahi i te ES-PLE mō te hydrolysis o ngā pūhui aliphatic me te ester, te whakataunga regioselective me te stereoselective rānei hei hanga i ngā waikawa chiral me ō rātou hua.

Momo tauhohenga whakakorikori:

Ngā Painga:

★ Teitei o te motuhaketanga o te papa.
★ He kaha te whiriwhiringa chiral.
★ Te tahuritanga teitei.
★ He iti ake ngā hua taha.
★ Ngā āhuatanga tauhohenga ngawari.
★ He pai mō te taiao.

Ngā tohutohu mō te whakamahi:

➢ I te nuinga o te wā, me whakauru te pūnaha tauhohenga i te matūriki, te otinga parepare me te ES-PLE. Ka mahia te whakahāngaitanga o ētahi ES-PLE i roto i te wāhanga waro.
➢ Me ako takitahi ngā momo ES-PLE katoa e pā ana ki ngā āhuatanga tauhohenga tino pai.

Ngā Tauira Taupānga:

Tauira 1 (Te Hanganga Koiora o te Pregabalin Intermediate)⁽¹⁾:

Tauira 2⁽²⁾:

Tauira 3⁽³⁾:

Tauira 4⁽⁴⁾:

Rokiroki:

Puritia mō ngā tau e rua i raro i te -20℃.

Whakarongo mai:

Kaua rawa e pā ki ngā āhuatanga tino kino pēnei i te: pāmahana teitei, pH teitei/iti.

Ngā Tohutoro:

1. Xu FX, Chen SY, Xu G, me ētahi atu. Appl. Biotechnol Bioproc E, 1988, 54(4): 1030.
2. Huang, FC, Lee, LF, Mittal, RSD e tal. J. Am. Chem.Soc, 1975, 97, 4144.
3. Kielbasinski, P., Goralczyk, P., Mikolajczyk, M., e tal. Synlett, 1994, 127.
4. Gais, HJ, Griebel, C., Buschmann, H. Tetrahedron:Asymmetry 2000, 11, 917

O mua: Te haurore epoxide (EH)

Panuku: Te whakapūmau i te hauwaiora (FDH)

Tuhia tō karere ki konei ka tuku mai ki a mātou