Ko te hua manu te tīmatanga o te oranga o te tangata, he pūtau hua manu kāore anō kia pakari, ā, ka tupu hei hua manu. Heoi, ka heke te kounga o ngā hua manu i te kaumātuatanga o ngā wāhine, nā ngā āhuatanga pēnei i te momona, ā, ko ngā hua manu kounga iti te tino take o te iti o te momonatanga o ngā wāhine momona. Heoi, he wero ki ngā kaipūtaiao te kimi me pēhea te whakapai ake i te kounga o ngā hua manu i roto i ngā wāhine momona.
Nō nā tata nei, i whakaputaina he rangahau i roto i te pukapuka Cell proliferation, ko te taitara ko Administration of nicotinamide mononucleotide improves oocyte quality of obese mouse. I kitea i roto i te rangahau ko te tāpiritanga o te nicotinamide adenine dinucleotide (NAD+) precursor.nikotīnamida mononukleosideKa taea e te waikawa (NMN) te whakapai ake i te mumura o ngā whatukuhu, te whakapai ake i te kounga o ngā hua manu, me te whakahoki mai i te taumaha o te tinana o te uri i roto i ngā kiore uwha momona.
I tīpakohia e ngā kairangahau he kiore uha e 3 wiki te pakeke me he kiore toa e 11 wiki te pakeke hei whakatū i tētahi tauira kiore mō te momona me te kai nui-ngako, ā, i whakamanahia mā te tuhi taumaha, te whakamātautau huka toto nohopuku, me te whakamātautau manawanui huka ā-waha, te wawaotanga kai 1 Mō ngā wiki e 2,NMNI werohia ngā tāpiringa mō ngā rā 10 karapīpiti hei kite i te whakaaturanga o ngā ira e pā ana ki te whanaketanga o te ovarian me ngā ira e pā ana ki te mumura, te rahi o te ngako o te kiko ngako o te puku, te taumata momo hāora tauhohe o ngā oocytes, te hanganga o te spindlechromosome, te mahi mitochondrial, te hihiri actin, me te kino o te DNA, ki te whakataurite ki ngā hua tatauranga e whakaatu ana:
1. I angitu te whakatūnga o tētahi tauira kiore momona i puta mai i te kai momona nui
Ko te uara FGB o te rōpū kai nui-ngako (HFD) he teitei ake i tērā o te rōpū kai noa (ND), hei tāpiri, i whakaatu ngā hua OGTT he koretake te huka o te rōpū kiore kai nui-ngako (HFD).
2. Ka taea e te NMN te whakapai ake i ngā āhuatanga rerekē o te pākia o te tinana i roto i ngā kiore HFD
Tāpiritanga kiNMNI whakaitihia e te tāpiringa te nui o te ngako i roto i ngā kiore i roto i te rōpū kai nui-ngako (HFD), ā, e whakaatu ana ngā hua he pānga tiaki tō te NMN ki te pākia o te pākia rerekē i roto i ngā kiore i roto i te rōpū kai nui-ngako (HFD).
3. Ka whakapai ake te NMN i te kounga ovarian i roto i ngā kiore HFD
Ka taea e te NMN te whakapai ake i te kounga o te whatukuhu i roto i ngā kiore kai nui-ngako (HFD) mā te whakahaere i te whakaaturanga o ngā ira matua e pā ana ki te whanaketanga o ngā whatukuhu o te whatukuhu (Bmp4, Lhx8) me te mumura.
4. Ka whakaitihia e te NMN ngā hapa wehenga oocyte me te kino o te DNA i roto i ngā kiore HFD
Ka taea e te NMN te whakaiti i te auau o ngā hapa o te taura me ngā hē o te ira tangata i puta mai i te kai momona nui (HFD), te whakaiti i te tohu γH2A.X, me te whakapai ake i te kino o te DNA i puta mai i te kai momona nui (HFD) mā te whakaiti i te whakaaturanga Bax.
5. Ka taea e te NMN te whakapai ake i te kounga o ngā oocytes
Ka taea e te NMN te whakatika i te whakahekenga o te whakaaturanga antioxidant SOD1 i roto i te rōpū kai nui te ngako (HFD), te whakapai ake i te tohatoha o ngā mitochondria, me te whakapai ake i te kounga o ngā oocytes mā te pupuri i te pumau o te cytoskeleton.
6. Ka taea e te NMN te whakahoki mai i te tohatoha o te pata ngako i roto i ngā kiore HFD
He paku teitei ake te nui o ngā huakita o te rōpū kai momona-nui (HFD) i tērā o ngā huakita o te rōpū kai noa (ND), ā, ka taea e te tāpiringa NMN te whakaiti i te kaha o te hihi o ngā pata ngako.
7. Ka whakahokia mai e te NMN te taumaha tinana o ngā uri o ngā kiore HFD
He iti iho te taumaha whānau o te uri o te rōpū kai nui-ngako (HFD) i tō te rōpū kai noa (ND), ā, nā te tāpiringa NMN i whakahoki mai te taumaha whānau o te uri o te rōpū HFD.
I roto i tēnei rangahau, i whakaaturia e ngā kairangahau mā roto i ngā whakamātautau kiore he kaha tō te NMN ki te whakapai ake i te kounga o ngā hua o te ira i roto i ngā kiore wahine momona i puta mai i te kai momona nui, ā, i whakakitea mai ka taea e te NMN te whakaora i te mahi mitochondrial me te whakaiti i te kohikohinga ROS i roto i ngā hua o te ira kiore wahine momona. , te kino o te DNA me ngā tikanga huna o te tohatoha pata lipid. Nō reira, ka whakaratohia e tēnei rangahau he rautaki rongoā pea mō te whakapai ake i ngā raruraru momona i puta mai i te momona i roto i ngā wāhine.
ngā tohutoro
1.Wang L, Chen Y, Wei J, et al. Ka whakapai ake te whakahaerenga o te nicotinamide mononucleotide i te kounga oocyte o ngā kiore momona. Cell Prolif. 2022; e13303. doi10. 1111cpr.13303
Wā tuku: Hepetema-28-2022